Characterization and Biological Evaluation of Propolis from Poland.

نویسندگان

  • Milena Popova
  • Efstathia Giannopoulou
  • Krystyna Skalicka-Woźniak
  • Konstantia Graikou
  • Jaroslaw Widelski
  • Vassya Bankova
  • Haralabos Kalofonos
  • Gregory Sivolapenko
  • Katarzyna Gaweł-Bęben
  • Beata Antosiewicz
  • Ioanna Chinou
چکیده

In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populusnigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populustremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95-1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25-1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health.

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عنوان ژورنال:
  • Molecules

دوره 22 7  شماره 

صفحات  -

تاریخ انتشار 2017